Saturday August 30, 2008
Catheter-Directed Embolectomy (CDE), Fragmentation, and Thrombolysis for the Treatment of Massive PE After Failure of Systemic Thrombolysis


Very interesting work from the Department of Radiology, Stanford University Medical Center, Stanford, CA.

A retrospective review was performed on 70 consecutive patients with suspected acute PE over a 10-year period (from 1997 to 2006) who had been referred for pulmonary angiography and/or intervention. The criteria for study inclusion were patients who received CDI due to angiographically confirmed massive PE and hemodynamic shock. CDI involved suction embolectomy and fragmentation with or without catheter thrombolysis.

Results: Twelve patients were treated with CDI. There were seven men and five women (mean age, 56 years; age range, 21 to 80 years). Seven patients (58%) were referred for CDI after failing systemic infusion with 100 mg of tissue plasminogen activator, and five patients (42%) had contraindications to systemic thrombolysis. Catheter-directed fragmentation and embolectomy were performed in all patients (100%). Additionally, catheter-guided thrombolysis was performed in eight patients (67%). Technical success was achieved in 12 of 12 cases (100%). There were no major procedural complications (0%). Significant hemodynamic improvement was observed in 10 of 12 cases (83%). The remaining two patients (17%) died secondary to cardiac arrest within 24 h. Ten of 12 patients (83%) survived and remained stable until hospital discharge.

Conclusion: In the setting of hemodynamic shock from massive PE, catheter-directed intervention (CDI) is potentially a life-saving treatment for patients who have not responded to or cannot tolerate systemic thrombolysis.



Reference: click to get abstract

Catheter-Directed Embolectomy, Fragmentation, and Thrombolysis for the Treatment of Massive Pulmonary Embolism After Failure of Systemic Thrombolysis - Chest. 2008; 134:250-254